Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer
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منابع مشابه
KLF 4 ( Kruppel - like factor 4 ( gut ) )
A full-length mouse cDNA clone encoding KLF4 was initially isolated from a NIH3T3 cDNA library by reduced stringency screening with a DNA probe containing the zinc finger region of an immediate early gene product, Zif268 or Egr1. A distinct feature of the KLF4 gene is the highly GC-rich nature of the sequence near its 5'-end. Thus, the G+C content of the 1000 nt 5'-flanking region is 67% and th...
متن کاملKruppel - like factor 4 ( KLF 4 ) and cancer literatures
Kruppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. KLF4 is also a tumor suppressor in certain cancers. KLF4 can be an indicator of stem-like capacity in embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs), etc. The KLF4 gene is conserved in chimpanzee, Rhesus monkey...
متن کاملKruppel like factor 4 ( KLF 4 ) : a transcription factor with diverse context - dependent functions Review
Hima Vangapandu1, Walden Ai1* Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Building 2, Room B18, Columbia, SC 29209, USA __________________________________________________________________________________________________ *Correspondence: Dr. Walden Ai, Assistant Professor, Department of Pathology, Microbiology and...
متن کاملPutative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma.
PURPOSE Krüppel-like factor 4 (KLF4) is a zinc-finger protein that plays important roles in stem cells and the development of gastric cancers. However, the role of KLF4 in primary lung cancer is unknown. The purpose of this study is to determine possible roles of KLF4 in lung cancer. EXPERIMENTAL DESIGN The KLF4 expression in primary lung cancer tissues and case-matched normal lung tissues we...
متن کاملKLF 5 ( Kruppel - like factor 5 ( intestinal ) )
KLF5 is a transcription factor. Many KLF5 target genes, such as PDGFa, PPARg, NFkB, cyclinD1, KLF4, and TCR, have been identified in different cell models. KLF5 regulates cell proliferation, cell cycle, apoptosis, and differentiation. KLF5 is an important transcription factor for cardiovascular remodeling and tumor angiogenesis. KLF5 is essential for mouse embryo development. Additionally, KLF5...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2017
ISSN: 1676-5680
DOI: 10.4238/gmr16019272